Born in Naples, Roberto Cominati began studying piano at a very early age: he was just eight when he was admitted to the Conservatory San Pietro a Majella in Naples for special merits. In 1991 he won the First Prize at the International Competition Alfredo Casella in Naples and in 1993 the First Prize at the International Competition Ferruccio Busoni in Bolzano; this last award launched his career and gained him the favour of both critics and major Italian concert promoters.

In 1999 he was rewarded the Jacques Stehman Prize by the audience of the RTBF and TV5 France at the Queen Elisabeth Competition. Since then, Roberto Cominati is invited to perform in the most prestigious venues and festivals such as the Salzburger Festspiele, Festival dei Due Mondi in Spoleto, Settimane Musicali di Stresa, Teatro alla Scala in Milan, Teatro Comunale in Bologna, Accademia Santa Cecilia in Rome, Teatro La Fenice in Venice, Teatro San Carlo in Naples, Lingotto in Turin, Kennedy Center in Washington D.C., Teatro Municipal in Saõ Paulo, Sydney Opera House, Théâtre du Châtelet in Paris, Théâtre Royal de la Monnaie in Brussels.

He has appeared with leading orchestras in Europe, Japan and Australia, under the baton of such conductors as Sir Simon Rattle, Andrey Boreyko, Leon Fleisher, Daniel Harding, Eliahu Inbal, Yuri Ahronovitch, David Robertson, Aleksandr Lazarev.

In 2010, Roberto Cominati recorded the complete of works Maurice Ravel for Amadeus.