Donald Weilerstein has concertized extensively as soloist and chamber musician throughout the world. For twenty years (1969-1989) he was the first violinist of the renowned Cleveland Quartet with whom he toured the world. His recordings with the quartet can be heard on the RCA, Telarc, CBS, Phillips, and Pro Arte labels. These recordings have earned seven Grammy nominations and won Best of the Year awards from Time and Stereo Review. He was a member of the Young Concert Artists and a participant in the Marlboro Music Festival, performing on several "Music from Marlboro" Tours. In 1968 he won the Munich International Competition for violin and piano duo. Currently, he is a member of the Weilerstein Trio, the trio-in-residence at the New England Conservatory of Music.

Donald Weilerstein has taught and performed at such major American and European music festivals as Tanglewood, Caramoor, Aspen, Ravinia, Marlboro, Mostly Mozart, Salzburg, Luzern, Verbier, Ishikawa, Keshet Eilon, "Chamber Music Encounters" sponsored by La Cité de la Musique and the Paris Conservatory, and many more. He regulary participates in the Yellow Barn Music Festival, the Banff Centre, and the Perlman Music Program. He has taught and perfromed in Shanghai, China as part of the Morningside Music Bridge and in Venezuela as part of El Sistema.

Formerly a professor of violin and chamber music at the Eastman School and the Cleveland Institute of Music, Donald Weilerstein is currently on the faculty of the New England Conservatory of Music. His students have been prize winners in major national and international competitions. His students can be heard in many of today's leading orchestras and chamber ensembles. He is also a faculty member at the Juilliard School.